Understanding why antibiotic allergy happens and how to improve care
Official title: Harnessing translational research to advance understanding and clinical care in antibiotic allergy
Funded at Brigham and Women's Hospital · NIH-11378721 · Data updated 2026-11-12
Researchers are exploring new ideas to understand and improve care for people who have antibiotic-related delayed allergic reactions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 24, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $434,854 |
| NIH project number | 5UG3AI190114-02 |
| Project ID | NIH-11378721 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals who have or may develop antibiotic-induced delayed-type hypersensitivity reactions and related skin or systemic manifestations.
✕Less likely to help
People without antibiotic allergies or who do not participate in any study-related activities are unlikely to benefit.
What this research studies
This grant aims to uncover what triggers antibiotic-induced delayed-type drug hypersensitivity beyond the usual immune players. It will study factors like regulatory T cell responses, co-existing infections, and the patient’s microbiome in both humans and mice. The study uses translational methods to connect laboratory findings with clinical presentation, with the goal of informing better diagnosis and treatment. If successful, the work could shift how clinicians predict risk and manage patients with antibiotic allergies.
Why it matters
Potential benefit: Could lead to better prediction, prevention, and management of antibiotic allergy for patients.
How similar studies have gone: Prior work has focused on T cells and HLA; this study tests novel factors and has potential for significant new insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Divito, Sherrie Jill — Brigham and Women's Hospital
- Study coordinator: Divito, Sherrie Jill
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.