Understanding the cellular interactions and molecular changes in ALS
Official title: Spatially Resolved Dynamics of Molecular Pathology and Intercellular Interactions in Amytrophic Lateral Sclerosis
Funded at New York Genome Center · NIH-10771178 · Data updated 2026-11-12
This study is looking at how different brain and spinal cord cells interact in people with ALS to better understand the disease and find new ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $526,777 |
| NIH project number | 5R01NS116350-05 |
| Project ID | NIH-10771178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Amyotrophic Lateral Sclerosis.
✕Less likely to help
Patients with other neurodegenerative diseases or those without a diagnosis of ALS may not benefit from this research.
What this research studies
This research investigates the complex interactions between different cell types in the brain and spinal cord of patients with Amyotrophic Lateral Sclerosis (ALS). By creating a detailed map of the molecular changes and spatial organization of these cells, the study aims to uncover how these factors contribute to the progression of ALS. The researchers will utilize advanced techniques to analyze the transcriptome and proteome of cellular subpopulations, comparing those from ALS patients to healthy controls. This approach may help identify new diagnostic markers and therapeutic targets for ALS.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for ALS patients.
How similar studies have gone: Previous research has shown promise in understanding neurodegenerative diseases through similar multi-omics approaches, indicating potential for success in this area.
Where this research is happening
-
New York Genome Center
New York, United States Active
Researchers
- Principal investigator: Phatnani, Hemali — New York Genome Center
- Study coordinator: Phatnani, Hemali
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.