ALS-FTSD: How brain regions and cells drive ALS and frontotemporal dementia together
Official title: Spatially resolved dynamics of molecular pathology and intercellular interactions in ALS-FTSD
Funded at New York Genome Center · NIH-11363959 · Data updated 2026-11-12
A research grant to study how specific brain regions and cellular changes relate to ALS and related frontotemporal dementia symptoms in people who have the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2020 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $715,672 |
| NIH project number | 2R01NS116350-06 |
| Project ID | NIH-11363959 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with ALS or ALS-FTSD and healthy controls who contribute tissue samples or participate in the study analyses.
✕Less likely to help
Patients without access to brain/nerve tissue samples or those not matching study criteria may not directly benefit.
What this research studies
This project uses advanced molecular techniques to map how different brain and spinal cord areas change at the cellular level in ALS and ALS-FTSD. Researchers compare patients with healthy controls to build a region-by-cellular map of disease features. The aim is to connect these molecular patterns to the clinical symptoms seen in ALS-FTSD so that future therapies can target the right spots in the nervous system.
Why it matters
Potential benefit: If successful, findings could lead to targeted therapies that address specific brain regions and cellular pathways involved in ALS-FTSD.
How similar studies have gone: Previous work has shown region-specific molecular changes in neurodegenerative diseases, supporting the potential for meaningful discoveries in ALS-FTSD.
Where this research is happening
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New York Genome Center
New York, United States Active
Researchers
- Principal investigator: Phatnani, Hemali — New York Genome Center
- Study coordinator: Phatnani, Hemali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.