New York Genome Center’s project on somatic mosaicism across human tissues
Official title: New York Genome Characterization Center: Somatic Mosaicism across Human Tissues
Funded at New York Genome Center · NIH-11408854 · Data updated 2026-11-12
A nationwide effort to build a high-quality catalog of somatic genetic changes found in healthy tissues from people of diverse backgrounds, with the goal of better understanding aging and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $6,304,619 |
| NIH project number | 4UM1DA058236-04 |
| Project ID | NIH-11408854 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals across diverse racial/ethnic backgrounds and a wide age range whose tissues may be studied for somatic mosaicism.
✕Less likely to help
People whose tissues are not included in the study or who choose not to participate may not benefit directly.
What this research studies
This program will map somatic variants across many tissues and ages, creating a shared resource that researchers can use to study how these mutations contribute to health and disease over a person’s life. It will generate and benchmark data from multiple tissues, develop standardized assays, and share the catalog with scientists to advance discoveries in cardiovascular, neurodegenerative, immune, and developmental conditions. Participants will contribute tissue samples and clinical information, enabling analyses that connect somatic mosaicism with disease pathways. The effort emphasizes quality control, data accessibility, and reproducibility to accelerate translational research.
Why it matters
Potential benefit: If successful, patients could benefit from earlier understanding of how somatic mutations influence aging and disease and from future diagnostic and treatment strategies informed by a comprehensive somatic mosaicism catalog.
How similar studies have gone: Previous work has linked somatic mosaicism to aging and certain diseases, and this program aims to extend those insights with a large, standardized data resource.
Where this research is happening
-
New York Genome Center
New York, United States Active
Researchers
- Principal investigator: Robine, Nicolas — New York Genome Center
- Study coordinator: Robine, Nicolas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.