Scalable multi-ancestry genomics to uncover blood and heart disease mechanisms
Official title: Scalable multi-ancestry functional genomics of blood traits and cardiovascular disease
Funded at New York Genome Center · NIH-11370700 · Data updated 2026-11-12
A multi-ancestry study will explore how genetic differences influence blood traits and cardiovascular disease using scalable functional genomics tools.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $780,943 |
| NIH project number | 5R01HL168247-03 |
| Project ID | NIH-11370700 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults from diverse ancestral backgrounds whose health records show cardiovascular risk or disease for potential future translational applications or biobank-based analyses.
✕Less likely to help
Individuals not represented in the study populations or those not contributing biological samples or data may receive no direct benefit.
What this research studies
This project aims to map which genetic variants actually cause heart disease and which cell types and genes they affect, focusing on blood-related pathways. Researchers will develop scalable methods to link noncoding variants to target genes across diverse populations. The work includes creating faster, higher-throughput experiments to connect variants with their functional outcomes in relevant cell types. Overall, the study seeks to break bottlenecks in translating GWAS findings into mechanistic insights that can guide therapies.
Why it matters
Potential benefit: If successful, results could lead to better understanding of why certain individuals are at higher risk and inform more precise prevention and treatment strategies for cardiovascular disease.
How similar studies have gone: Previous multi-ancestry GWAS efforts have shown promise in improving variant interpretation, with ongoing work expanding functional follow-up.
Where this research is happening
-
New York Genome Center
New York, United States Active
Researchers
- Principal investigator: Sanjana, Neville — New York Genome Center
- Study coordinator: Sanjana, Neville
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.