Understanding psoriasis genetic signals across diverse populations
Official title: Integrative and trans-ethnic study to understand psoriasis associated signals
Funded at University of Michigan at Ann Arbor · NIH-11404901 · Data updated 2026-11-12
A study to uncover the genetic factors behind psoriasis in African American people using advanced genomic and epigenetic methods.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 21, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $357,729 |
| NIH project number | 5R01AR080662-04 |
| Project ID | NIH-11404901 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with psoriasis or those at risk who identify as African American or have African ancestry and are willing to provide genetic/biological samples.
✕Less likely to help
Patients without African ancestry or those not contributing genetic/biological samples may experience indirect benefits through broader scientific advances.
What this research studies
This project will combine multi-ethnic genetic data with ATAC-seq and other genomic tools to map how genetic variants influence psoriasis in keratinocytes. By focusing on African ancestry and African American individuals, researchers aim to pinpoint causal variants and their mechanisms in NF-kB signaling. The study plans to integrate genetic, epigenetic, and genomic information to improve our understanding of why psoriasis develops and varies across populations. Results could guide more precise therapies that consider ancestry-specific biology.
Why it matters
Potential benefit: If successful, this work could lead to more personalized treatments for psoriasis that account for genetic differences in African American patients.
How similar studies have gone: Previous multi-ethnic genetic studies have shown promise in identifying population-specific disease signals, with increasing success as sample diversity grows.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Tsoi, Lam Cheung — University of Michigan at Ann Arbor
- Study coordinator: Tsoi, Lam Cheung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.