Anchored versus circulating enzyme therapy to calm psoriasis inflammation
Tissue-Anchored vs. Circulating Engineered Enzyme Constructs for Immunometabolic Resolution of Psoriasis
Compares two ways of giving engineered enzyme medicines to help people with psoriasis reduce chronic skin inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11262251 on NIH RePORTER |
What this research studies
If you have psoriasis, this project compares new engineered enzyme medicines given either anchored to the skin or delivered into the bloodstream. Researchers will examine how these enzymes change immune cell metabolism and behavior so inflammation can move back toward normal. The work begins with lab studies on human cells and tissue models and may guide future treatments for people. The aim is to learn which delivery approach better controls skin inflammation while limiting side effects.
Who could benefit from this research
Good fit: Adults with active, moderate-to-severe psoriasis and ongoing skin inflammation would be the most likely candidates for this work.
Not a fit: People with mild psoriasis that is well controlled, or those who cannot receive enzyme-based biologic treatments, may be unlikely to benefit directly from this research.
Why it matters
Potential benefit: Could provide a new way to reduce chronic skin inflammation and prevent long-term tissue damage in psoriasis.
How similar studies have performed: Enzyme- and biologic-based therapies have shown promise in preclinical studies and some clinical uses, but tissue-anchored enzyme delivery is a newer and less-tested approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Keselowsky, Benjamin George — University of Florida
- Study coordinator: Keselowsky, Benjamin George
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.