SerpinB3 and keratinocytes: a new path to understanding psoriasis
Official title: A mechanistic investigation of SerpinB3 and its role in psoriasis
Funded at Arizona State University-Tempe Campus · NIH-11375450 · Data updated 2026-11-12
This NIH grant explores how a keratinocyte protein called SerpinB3 may drive plaque psoriasis, with the hope of finding new treatments for people with moderate-to-severe disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | July 2, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $401,753 |
| NIH project number | 5R01AR085579-02 |
| Project ID | NIH-11375450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with moderate-to-severe plaque psoriasis and willingness to provide skin samples or participate in related studies.
✕Less likely to help
People without psoriasis or those not eligible for skin-sample analyses may not benefit from this specific research.
What this research studies
Psoriasis is a common skin condition that can cause painful, scaly plaques and is linked with anxiety and other health problems. The project focuses on SerpinB3, a protein in skin cells, to understand how it might contribute to the disease process in psoriasis. By studying how SerpinB3 and related immune signals interact in the skin, researchers aim to uncover mechanisms that could be targeted by new therapies. The work involves laboratory studies and analyses that could translate into future clinical options for patients who need better treatment options.
Why it matters
Potential benefit: If successful, the work could lead to new therapeutic strategies for plaque psoriasis that are more effective or affordable.
How similar studies have gone: Previous studies have linked SerpinB3 to psoriatic pathology, but definitive mechanisms remain to be clarified, making this area promising but still exploratory.
Where this research is happening
-
Arizona State University-Tempe Campus
Scottsdale, United States Active
Researchers
- Principal investigator: Yaron, Jordan Robin — Arizona State University-Tempe Campus
- Study coordinator: Yaron, Jordan Robin
Related research
Other NIH-funded projects on the same topics.
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Testing antiplatelet approaches in psoriasis to improve blood vessel health
A study at NYU School of Medicine will test antiplatelet strategies to reduce heart and blood vessel risk in adults with psoriasis.
-
Topical immunoregulatory therapy for psoriasis
A new topical treatment for psoriasis is being developed to safely reduce skin symptoms and improve quality of life.
-
Understanding psoriasis genetic signals across diverse populations
A study to uncover the genetic factors behind psoriasis in African American people using advanced genomic and epigenetic methods.
-
Role of a skin protein in psoriasis-related diabetes
A study explores how a skin inflammation signal may contribute to developing type 2 diabetes in people with psoriasis.
-
How satisfied people with plaque psoriasis are with their treatments
This project will try a new questionnaire called DermSat to measure treatment satisfaction among people with plaque psoriasis.
-
Anchored versus circulating enzyme therapy to calm psoriasis inflammation
Compares two ways of giving engineered enzyme medicines to help people with psoriasis reduce chronic skin inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.