Understanding how the heart's structure changes in heart failure
Official title: Extracellular matrix turnover in pathological cardiac remodeling
Funded at University of Colorado Denver · NIH-11043446 · Data updated 2026-11-12
This study is looking at how the heart's support structure changes when someone has heart failure, with the hope of finding new ways to help treat and improve heart health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | March 1, 2024 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $524,090 |
| NIH project number | 5R01HL169473-02 |
| Project ID | NIH-11043446 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure or related cardiac conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those without heart failure may not benefit from this research.
What this research studies
This research investigates the changes in the extracellular matrix of the heart during heart failure, which is a major cause of illness and death. By studying how the matrix is built and broken down in failing hearts, researchers aim to identify new targets for therapies that could slow or reverse heart disease progression. The approach involves advanced techniques to analyze protein changes in heart tissue over time, providing insights into the underlying mechanisms of cardiac dysfunction. Patients may benefit from potential new treatments developed from this understanding.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and outcomes for patients with heart failure.
How similar studies have gone: Previous research has shown promise in understanding cardiac remodeling, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Lau, Edward — University of Colorado Denver
- Study coordinator: Lau, Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.