Understanding how specific proteins interact in craniofacial development
Official title: Characterization of PDGFR alpha/beta heterodimers
Funded at University of Colorado Denver · NIH-10923825 · Data updated 2026-11-12
This study is looking at how certain proteins in our bodies might affect the development of facial features, especially to understand why some babies are born with conditions like cleft lip and palate, with the hope of finding ways to prevent or treat these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $81,895 |
| NIH project number | 5F32DE032554-02 |
| Project ID | NIH-10923825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with craniofacial malformations, such as cleft lip or palate, particularly those who are 21 years or older.
✕Less likely to help
Patients with craniofacial conditions unrelated to PDGFR signaling may not benefit from this research.
What this research studies
This research investigates the role of platelet-derived growth factor receptors (PDGFRs) in the development of craniofacial structures, focusing on how their interactions can lead to common birth defects like cleft lip and palate. By using advanced techniques to observe these protein interactions in both laboratory settings and living organisms, the study aims to uncover the mechanisms behind these signaling pathways. The goal is to identify how different PDGFR dimers function and interact, which could provide insights into preventing or treating craniofacial malformations.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating craniofacial birth defects.
How similar studies have gone: Previous research has shown promising results in understanding protein interactions in developmental biology, suggesting potential for success in this area.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Campana, Maria B — University of Colorado Denver
- Study coordinator: Campana, Maria B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.