Understanding how proteins transport materials within cells
Official title: Functional protein disorder in intracellular transport
Funded at University of Colorado Denver · NIH-11005993 · Data updated 2026-11-12
This study is looking at how certain proteins help move important materials inside our cells, which could help us understand problems related to brain development and colon cancer, and possibly lead to new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $275,100 |
| NIH project number | 1R35GM156171-01 |
| Project ID | NIH-11005993 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or those affected by neurodegenerative diseases and colon cancer.
✕Less likely to help
Patients with conditions unrelated to intracellular transport mechanisms or those not diagnosed with the specified disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which proteins, specifically dynein and kinesin motor complexes, transport essential materials within human cells. By utilizing advanced techniques like cryo-electron microscopy and artificial intelligence, the study aims to uncover the structural and functional roles of disordered protein regions in this transport process. The findings could provide insights into how misregulation of these proteins is linked to neurodevelopmental disorders and colon cancer, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions like autism spectrum disorder and colon cancer.
How similar studies have gone: Previous research has shown promise in understanding protein transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Vogeli, Beat Rolf — University of Colorado Denver
- Study coordinator: Vogeli, Beat Rolf
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.