Understanding how proteins involved in cerebral cavernous malformations work
Official title: Signaling mechanisms of the cerebral cavernous malformations protein complex
Funded at Yale University · NIH-11095907 · Data updated 2026-11-12
This study is looking at how certain proteins help keep blood vessels in the brain healthy and how changes in specific genes can lead to problems like strokes and seizures, so we can better understand and hopefully improve treatments for people with cerebral cavernous malformations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $555,030 |
| NIH project number | 5R01NS134606-02 |
| Project ID | NIH-11095907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cerebral cavernous malformations due to mutations in the KRIT1, CCM2, or CCM3 genes.
✕Less likely to help
Patients without cerebral cavernous malformations or those whose condition is not linked to the specific genetic mutations being studied may not benefit from this research.
What this research studies
This research investigates the signaling mechanisms of proteins that are crucial for maintaining the integrity of blood vessels in the brain. It focuses on how mutations in specific genes lead to cerebral cavernous malformations, which can cause serious neurological issues like strokes and seizures. By examining the interactions and functions of these proteins, the researchers aim to uncover the underlying mechanisms that contribute to the disease. This work involves advanced biochemical techniques and collaborative efforts between multiple research teams to fill critical gaps in knowledge about these protein complexes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cerebral cavernous malformations and improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the roles of similar protein complexes in other vascular diseases, suggesting potential for success in this area as well.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Boggon, Titus Jonathon — Yale University
- Study coordinator: Boggon, Titus Jonathon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.