Understanding how platelets affect CD8+ T cells in sepsis
Official title: Understanding the Platelet-CD8+ T Cell Interactions in Sepsis
Funded at Bloodworks · NIH-11392516 · Data updated 2026-11-12
A study in Seattle will explore how platelets communicate with CD8+ T cells during sepsis and whether this interaction contributes to worsening illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bloodworks NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $483,144 |
| NIH project number | 5R35GM160360-02 |
| Project ID | NIH-11392516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with sepsis or a history of sepsis who consent to participate or provide samples.
✕Less likely to help
Patients not eligible due to enrollment criteria or inability to provide samples may not benefit.
What this research studies
This project looks at the link between platelets and CD8+ T cells in people with sepsis. Researchers will study platelet MHC-I activity and its role in suppressing CD8+ T cells, using both patient samples and animal models. The goal is to see if platelet–CD8+ T cell clusters appear in septic patients and if they predict worse outcomes, and to identify which CD8+ T cell subsets are most affected. The work aims to uncover mechanisms that could lead to new therapies to prevent chronic critical illness after sepsis.
Why it matters
Potential benefit: If successful, the research could identify new targets to prevent CD8+ T cell suppression and improve recovery after sepsis.
How similar studies have gone: Preliminary work suggests platelet MHC-I involvement in T cell regulation, with potential translational implications for sepsis.
Where this research is happening
-
Bloodworks
Seattle, United States Active
Researchers
- Principal investigator: Guo, Li — Bloodworks
- Study coordinator: Guo, Li
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.