Understanding how OTX2 gene regulation affects retinal development
Official title: In The Loop: Investigating Enhancer-Mediated Regulation of OTX2 During Retinal Development
Funded at University of Colorado Denver · NIH-10912501 · Data updated 2026-11-12
This study is looking at how a gene called OTX2 helps the retina develop properly, which is important for good vision, and it aims to find out how changes in DNA can affect this process, so that we can better understand and help people with retinal diseases related to OTX2.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $37,272 |
| NIH project number | 5F31EY034794-02 |
| Project ID | NIH-10912501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with retinal disorders or those at risk of developing such conditions.
✕Less likely to help
Patients with retinal conditions unrelated to OTX2 or those over 21 years old may not benefit from this research.
What this research studies
This research investigates the role of the OTX2 gene in the development of the retina, which is crucial for vision. By using advanced techniques like CRISPR to manipulate specific DNA regions known as enhancers, the study aims to uncover how these enhancers control the expression of OTX2 during different stages of retinal development. The research focuses on understanding the timing and location of OTX2 expression, which is vital for the formation of essential retinal cell types. Patients may benefit from insights gained into retinal diseases linked to OTX2 dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating retinal diseases that affect vision.
How similar studies have gone: Previous research has shown success in using CRISPR techniques to manipulate gene expression, suggesting potential for impactful findings in this area.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Purvis, Ian J — University of Colorado Denver
- Study coordinator: Purvis, Ian J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.