Understanding how myelin changes in response to brain activity
Official title: Examining the regulation of resident mRNAs in myelinplasticity
Funded at University of Colorado Denver · NIH-11081801 · Data updated 2026-11-12
This study is looking at how the protective covering around nerve fibers, called myelin, changes when we learn new skills or have different sensory experiences, and it’s for anyone interested in understanding how our brains adapt to support our actions and behaviors.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | May 9, 2023 |
| Project end | May 8, 2026 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 5F32NS131216-03 |
| Project ID | NIH-11081801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting myelin, such as multiple sclerosis or other demyelinating diseases.
✕Less likely to help
Patients with conditions unrelated to myelin or those who do not have neurological disorders may not benefit from this research.
What this research studies
This research investigates how myelin, the protective sheath around nerve fibers, adapts in response to various stimuli such as motor learning and sensory experiences. By examining the molecular and cellular mechanisms that regulate myelin plasticity, the study aims to uncover how individual myelin sheaths respond to the needs of specific axons. The research employs advanced techniques to analyze the signaling processes between axons and oligodendrocytes, the cells responsible for myelination. This work could provide insights into the adaptability of neural circuits and how they support behavioral changes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain function and recovery from neurological conditions.
How similar studies have gone: Previous research has shown promising results in understanding myelin plasticity, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Adula, Kadidia Pemba — University of Colorado Denver
- Study coordinator: Adula, Kadidia Pemba
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.