Understanding how LSD1 affects blood cell development
Official title: Establishing the role and mechanisms of LSD1 during megakaryocytic and erythroid fate commitment
Funded at Yale University · NIH-11009038 · Data updated 2026-11-12
This study is looking at a protein called LSD1 to see how it helps blood cell progenitor cells decide whether to become red blood cells or platelets, which could help us understand blood disorders better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $51,974 |
| NIH project number | 5F31HL167628-03 |
| Project ID | NIH-11009038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be experiencing blood-related conditions, particularly those related to anemia.
✕Less likely to help
Patients with acute blood disorders or those who are not experiencing issues with blood cell formation may not benefit from this research.
What this research studies
This research investigates the role of a protein called LSD1 in the development of blood cells, specifically focusing on how it influences the fate of progenitor cells that can become either red blood cells or platelets. By studying human blood cell progenitors in the laboratory, the researchers aim to uncover the mechanisms that guide these cells in their differentiation process. The approach involves using advanced techniques to analyze changes in gene expression and cell behavior when LSD1 is inhibited. This could provide insights into how disruptions in blood cell formation can lead to various blood disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating blood disorders such as anemia.
How similar studies have gone: Previous research has shown that understanding the genetic and epigenetic factors in blood cell development can lead to significant advancements in treating blood disorders, suggesting this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Thompson, Evrett — Yale University
- Study coordinator: Thompson, Evrett
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.