Understanding how heart development affects lymphatic function in children with congenital heart disease.
Official title: The Second Heart Field in Lymphovenous Valve Development: Understanding Lymphatic Dysfunction in Congenital Heart Disease
Funded at Rutgers Biomedical and Health Sciences · NIH-11070797 · Data updated 2026-11-12
This study is looking at how certain cells help create important valves in the lymphatic system, which can affect kids with congenital heart disease, and it hopes to find better ways to understand and treat any related issues they might have.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | December 27, 2024 |
| Project end | June 26, 2029 |
| Funding year | 2025 |
| Award (this year) | $44,880 |
| NIH project number | 1F30HL178304-01 |
| Project ID | NIH-11070797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old diagnosed with congenital heart disease, particularly those with 22q11 deletion syndrome.
✕Less likely to help
Patients with congenital heart disease who do not have associated lymphatic dysfunction may not benefit from this research.
What this research studies
This research investigates the role of a specific group of cells, known as the second heart field, in the development of lymphovenous valves, which are crucial for proper lymphatic function. By studying how these cells contribute to the formation of these valves, the research aims to uncover the underlying causes of lymphatic dysfunction in children with congenital heart disease (CHD). The approach includes advanced techniques to analyze the development of these valves and their connection to heart function. The findings could lead to better understanding and treatment options for children suffering from related lymphatic conditions.
Why it matters
Potential benefit: If successful, this research could improve treatment strategies for children with congenital heart disease and associated lymphatic disorders.
How similar studies have gone: While research on congenital heart disease is extensive, the specific focus on the second heart field's role in lymphatic valve development is relatively novel and has not been extensively tested.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Vyzas, Christina — Rutgers Biomedical and Health Sciences
- Study coordinator: Vyzas, Christina
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.