Understanding how genetic variations affect human traits
Official title: Multi-scale functional dissection and modeling of regulatory variation associated with human traits
Funded at Yale University · NIH-11047683 · Data updated 2026-11-12
This study is looking at how certain genetic differences can affect our health and traits, using cutting-edge tools to understand how these changes influence our bodies, and it aims to help create personalized treatments for patients based on their unique genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 16, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $757,328 |
| NIH project number | 5R01HG012872-03 |
| Project ID | NIH-11047683 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with known genetic variations that may influence metabolic traits or disease risk.
✕Less likely to help
Patients without significant genetic variations or those not affected by metabolic traits may not benefit from this research.
What this research studies
This research investigates the genetic variations that influence human traits and diseases, focusing on regulatory regions of the genome. By employing advanced techniques like CRISPR, the team aims to identify how specific genetic mutations affect gene regulation and contribute to various metabolic traits. The project will create a comprehensive catalog of these regulatory variants, enhancing our understanding of their roles in health and disease. Patients may benefit from insights that could lead to personalized treatments based on their genetic makeup.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases linked to genetic variations.
How similar studies have gone: Previous research has shown promise in understanding genetic variations through similar approaches, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Reilly, Steven K. — Yale University
- Study coordinator: Reilly, Steven K.
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.