Understanding how genetic variations affect human traits
Multi-scale functional dissection and modeling of regulatory variation associated with human traits
This study is looking at how certain genetic differences can affect our health and traits, using cutting-edge tools to understand how these changes influence our bodies, and it aims to help create personalized treatments for patients based on their unique genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11047683 on NIH RePORTER |
What this research studies
This research investigates the genetic variations that influence human traits and diseases, focusing on regulatory regions of the genome. By employing advanced techniques like CRISPR, the team aims to identify how specific genetic mutations affect gene regulation and contribute to various metabolic traits. The project will create a comprehensive catalog of these regulatory variants, enhancing our understanding of their roles in health and disease. Patients may benefit from insights that could lead to personalized treatments based on their genetic makeup.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known genetic variations that may influence metabolic traits or disease risk.
Not a fit: Patients without significant genetic variations or those not affected by metabolic traits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases linked to genetic variations.
How similar studies have performed: Previous research has shown promise in understanding genetic variations through similar approaches, indicating potential for success in this area.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Reilly, Steven K. — Yale University
- Study coordinator: Reilly, Steven K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.