Understanding how genes create differences in cell behavior
Official title: Genomic encoding of heterogeneity
Funded at Yale University · NIH-10909556 · Data updated 2026-11-12
This study is looking at how the same type of cells, like embryonic stem cells, can act differently even though they have the same genes, and it aims to find out how outside factors influence these differences, which could help us understand cancer and other health problems better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 25, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,507,500 |
| NIH project number | 1DP2HG014283-01 |
| Project ID | NIH-10909556 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or conditions where cell behavior and gene expression variability play a significant role.
✕Less likely to help
Patients with conditions that do not involve significant cellular heterogeneity or those who are not affected by cancer may not benefit from this research.
What this research studies
This research investigates how cells can exhibit different behaviors and characteristics despite having the same genetic information. By focusing on embryonic stem cells, the study aims to uncover the regulatory mechanisms that lead to variations in gene expression and behavior among cells. The researchers will explore how non-genetic factors contribute to this heterogeneity, particularly in the context of cancer and other health issues. This work could provide insights into how cells communicate and function differently, which is crucial for understanding development and disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancers and other conditions by targeting the underlying mechanisms of cell behavior variability.
How similar studies have gone: Other research has shown promise in understanding gene expression variability in cell systems, indicating that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Garg, Salil — Yale University
- Study coordinator: Garg, Salil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.