NIH-funded research R03 grant

Understanding how fear of falling affects daily life in multiple sclerosis

Official title: Development of a conceptual model and measure of the impact of fear of falling in multiple sclerosis.

Funded at University of Michigan at Ann Arbor · NIH-11301611 · Data updated 2026-11-12

This project creates a new way to measure how fear of falling changes daily activities for people with multiple sclerosis.

More Multiple Sclerosis research and trials

Quick facts

Grant typeR03 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor
NIH-funded
Lab location1 site (Ann Arbor, United States)
Project startJune 1, 2026
Project endMay 31, 2028
Funding year2026
Award (this year)$312,000
NIH project number1R03HD117818-01A1
Project IDNIH-11301611 on NIH RePORTER

Who could benefit from this research

Could help

Adults with multiple sclerosis experiencing gait or balance issues and fear of falling.

Less likely to help

Individuals without MS or without fall-related concerns are unlikely to benefit from this measure development project.

What this research studies

People with MS often worry about falling, which can limit daily activities and reduce quality of life. The team aims to develop a conceptual model and a practical measure that captures how fear of falling affects everyday tasks, beyond existing scales. By focusing on real-life impact, the work could inform better rehabilitation strategies and patient-centered care. The study uses a mix of clinical insights and patient input to create a tool that reflects daily living, not just movement or balance alone.

Why it matters

Potential benefit: If successful, patients with MS could receive more accurate assessments of how fear of falling limits their daily activities and get tailored interventions to maintain independence.

How similar studies have gone: Existing FoF measures exist but do not fully capture the impact on daily living; this project seeks to fill that gap with a new comprehensive metric.

Where this research is happening

  • University of Michigan at Ann Arbor
    Ann Arbor, United States
    Active

Researchers

  • Principal investigator: Abou, Libak — University of Michigan at Ann Arbor
  • Study coordinator: Abou, Libak

Related research

Other NIH-funded projects on the same topics.

  • Understanding the fear of falling in people with Multiple Sclerosis

    This study looks at how the fear of falling affects people with Multiple Sclerosis and aims to understand why this fear happens, so we can find better ways to help them feel more confident and safe on their feet.

    NIH research Wayne State University · Detroit, United States · NIH-10993952

  • Susceptibility-based MRI biomarkers for multiple sclerosis

    A short-term study aims to test MRI biomarkers that could help diagnose and predict MS in patients, using advanced imaging techniques.

    NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11631162

  • Ketamine to boost fear extinction and memory on PTSD patients

    A study testing whether ketamine can help people with PTSD better relearn and forget fear when given in a guided treatment plan.

    NIH research Yale University · New Haven, United States · NIH-11592530

  • Metabolic effects of PFAS exposure in the Cape Fear Basin (GenX Exposure Study)

    This NIH grant studies how PFAS chemicals in drinking water may affect metabolism and weight-related health in adults and children living along the Cape Fear River.

    NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11541905

  • Mediterranean-style eating and aging in people with multiple sclerosis

    This project looks at whether following a Mediterranean-style diet is linked to slower biological aging and less brain shrinkage in people living with multiple sclerosis.

    NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11492803

  • Inflammation and fear learning in PTSD

    This study looks at how a temporary inflammatory challenge affects fear extinction in people with and without PTSD to better understand how PTSD could be treated.

    NIH research Northern California Institute/res/edu · San Francisco, United States · NIH-11468318

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.