Metabolic effects of PFAS exposure in the Cape Fear Basin (GenX Exposure Study)
Official title: Metabolic impacts of PFAS exposure in the Cape Fear Basin: GenX Exposure Study
Funded at North Carolina State University Raleigh · NIH-11541905 · Data updated 2026-11-12
This NIH grant studies how PFAS chemicals in drinking water may affect metabolism and weight-related health in adults and children living along the Cape Fear River.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $4,233,899 |
| NIH project number | 1R01ES039536-01 |
| Project ID | NIH-11541905 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants include adults and children in the three exposed NC communities who have lived in areas reliant on PFAS-contaminated water for a substantial period.
✕Less likely to help
Individuals with no PFAS exposure or not meeting residence duration criteria may have limited direct benefit from this study.
What this research studies
PFAS chemicals from drinking water are being studied in three NC communities to understand how exposure relates to lipid disorders and obesity. Researchers will work with local community groups to measure PFAS levels in people and assess metabolic health markers. The study aims to connect environmental exposure with real-world health impacts and inform protective actions for families. Participation may involve health questionnaires, sample collection, and community-engaged research activities.
Why it matters
Potential benefit: If successful, findings could help communities reduce PFAS exposure and guide public health interventions to prevent obesity and lipid disorders associated with these chemicals.
How similar studies have gone: Previous PFAS exposure studies have linked certain PFAS to metabolic changes, supporting the relevance of this research.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Hoppin, Jane — North Carolina State University Raleigh
- Study coordinator: Hoppin, Jane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.