Understanding how early life neglect affects brain development and memory.
Microglial TREM2 Mediates Hippocampal Synaptic and Cognitive Sequela of Early Deprivation and Enrichment
This study looks at how not getting enough care early in life affects brain development, especially in areas important for memory, and it aims to find ways to help kids who have faced neglect by understanding how certain brain cells can be improved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11049675 on NIH RePORTER |
What this research studies
This research investigates the impact of early life neglect on brain development, particularly focusing on the hippocampus, which is crucial for memory. Using a mouse model, the study examines how limited resources during early life lead to cognitive deficits and structural changes in the brain. The researchers aim to understand the role of the TREM2 receptor on microglia, which are brain cells involved in synaptic pruning, and how enhancing this receptor can potentially reverse the negative effects of early deprivation. By exploring these mechanisms, the research seeks to provide insights that could inform interventions for children who have experienced neglect.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be children aged 0-11 years who have experienced neglect or adverse early life conditions.
Not a fit: Patients who have not experienced early life neglect or related cognitive deficits may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to improve cognitive function in children affected by early life neglect.
How similar studies have performed: While this research explores novel mechanisms, previous studies have shown that addressing early life adversities can lead to significant improvements in cognitive outcomes.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Kaffman, Arie — Yale University
- Study coordinator: Kaffman, Arie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.