Understanding how doctors choose treatments to improve advanced prostate cancer care
Official title: Improving outcomes of patients with advanced prostate cancer through a better understanding of provider decision-making
Funded at Duke University · NIH-11395342 · Data updated 2026-11-12
A clinician-researcher at Duke is exploring how medical decisions are made in advanced prostate cancer to help patients get better, fairer care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $144,761 |
| NIH project number | 5K08CA267062-05 |
| Project ID | NIH-11395342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with advanced prostate cancer who may face multiple treatment options and variations in care.
✕Less likely to help
Patients receiving only one standard treatment with no diversity in options or no disparities in care may see limited direct benefit.
What this research studies
This project looks at how doctors decide among different treatments for men with advanced prostate cancer, with attention to how factors like race, income, and care setting influence choices. It uses both numbers and interviews to understand decision-making and how trial design could support better care. The goal is to translate insights into policies or interventions that improve outcomes and reduce disparities for patients. The work is led by a Duke urologic oncologist with training in health services research and is designed to inform future clinical trials and treatment guidelines.
Why it matters
Potential benefit: If successful, the research could lead to fairer, more effective treatment decisions and policies that improve survival and quality of life for men with advanced prostate cancer.
How similar studies have gone: Previous work shows that provider choice and system factors influence treatment patterns; this study aims to build on that with more detailed analyses and policy-oriented outcomes.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kaye, Deborah R. — Duke University
- Study coordinator: Kaye, Deborah R.
Related research
Other NIH-funded projects on the same topics.
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Understanding how doctors make decisions for advanced prostate cancer treatment
This study looks at how doctors decide on treatments for patients with advanced prostate cancer, focusing on what influences their choices and how those choices affect patient care, with the hope of finding ways to improve treatment for everyone facing this tough diagnosis.
-
Using blood tests and single-cell epigenetics to detect aggressive changes in prostate cancer
Researchers will use blood-based liquid biopsies and single-cell epigenetic tests to look for early signs that prostate cancer is becoming resistant to hormone treatments in men with advanced disease.
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Drug that blocks tumor-made male hormones and the androgen receptor for advanced prostate cancer
A new medicine aims to block both the androgen receptor and the tumor’s own production of male hormones to help men with advanced, treatment‑resistant prostate cancer.
-
Boosting a tumor-suppressing enzyme to fight advanced prostate cancer
A research grant aims to develop new molecules that enhance the PP2A enzyme to slow or stop progression of advanced prostate cancer.
-
Modulating Androgen Signals to Boost CAR T Therapy for Prostate Cancer
A new approach uses CAR T cells targeting STEAP1 to treat advanced prostate cancer, with a focus on how androgen signals affect treatment effectiveness.
-
Genomic clues to guide therapy in advanced prostate cancer
This grant looks at how a patient’s tumor and germline DNA could predict which targeted or immune therapies will work best for advanced prostate cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.