Understanding how doctors make decisions for advanced prostate cancer treatment
Official title: Improving outcomes of patients with advanced prostate cancer through a better understanding of provider decision-making
Funded at Duke University · NIH-10897019 · Data updated 2026-11-12
This study looks at how doctors decide on treatments for patients with advanced prostate cancer, focusing on what influences their choices and how those choices affect patient care, with the hope of finding ways to improve treatment for everyone facing this tough diagnosis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $144,761 |
| NIH project number | 5K08CA267062-03 |
| Project ID | NIH-10897019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with advanced prostate cancer who are receiving or considering treatment.
✕Less likely to help
Patients with early-stage prostate cancer or those not seeking treatment may not benefit from this research.
What this research studies
This research investigates the decision-making processes of healthcare providers treating patients with advanced prostate cancer. It aims to identify the factors that influence treatment choices, including economic and non-economic aspects, and how these decisions impact patient outcomes. By analyzing variations in treatment based on provider specialty, location, and patient demographics, the study seeks to uncover disparities in care and develop strategies to improve treatment recommendations. The ultimate goal is to enhance the quality of care and outcomes for patients facing this challenging diagnosis.
Why it matters
Potential benefit: If successful, this research could lead to more effective and equitable treatment options for patients with advanced prostate cancer.
How similar studies have gone: Previous research has shown that understanding provider decision-making can lead to improved patient outcomes, indicating that this approach has potential for success.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kaye, Deborah R. — Duke University
- Study coordinator: Kaye, Deborah R.
Related research
Other NIH-funded projects on the same topics.
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Understanding how doctors choose treatments to improve advanced prostate cancer care
A clinician-researcher at Duke is exploring how medical decisions are made in advanced prostate cancer to help patients get better, fairer care.
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Using blood tests and single-cell epigenetics to detect aggressive changes in prostate cancer
Researchers will use blood-based liquid biopsies and single-cell epigenetic tests to look for early signs that prostate cancer is becoming resistant to hormone treatments in men with advanced disease.
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Drug that blocks tumor-made male hormones and the androgen receptor for advanced prostate cancer
A new medicine aims to block both the androgen receptor and the tumor’s own production of male hormones to help men with advanced, treatment‑resistant prostate cancer.
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Boosting a tumor-suppressing enzyme to fight advanced prostate cancer
A research grant aims to develop new molecules that enhance the PP2A enzyme to slow or stop progression of advanced prostate cancer.
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Modulating Androgen Signals to Boost CAR T Therapy for Prostate Cancer
A new approach uses CAR T cells targeting STEAP1 to treat advanced prostate cancer, with a focus on how androgen signals affect treatment effectiveness.
-
Genomic clues to guide therapy in advanced prostate cancer
This grant looks at how a patient’s tumor and germline DNA could predict which targeted or immune therapies will work best for advanced prostate cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.