Understanding how DNA is replicated during cell division
Official title: Molecular mechanisms of DNA replication in mitosis
Funded at University of Colorado Denver · NIH-11018441 · Data updated 2026-11-12
This study is looking at how cells copy their DNA during cell division, especially when some DNA is left over from earlier, and it's for anyone interested in understanding how mistakes in this process can lead to health problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | December 17, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $390,000 |
| NIH project number | 1R35GM156773-01 |
| Project ID | NIH-11018441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to DNA replication errors or aneuploidy.
✕Less likely to help
Patients with stable genetic conditions unrelated to DNA replication or aneuploidy may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind DNA replication that occurs during mitosis, the phase of the cell cycle when chromosomes are separated into two new cells. It aims to uncover how cells manage to replicate any remaining DNA that wasn't completed during the earlier S phase of the cell cycle. Using purified proteins from budding yeast, the study will employ biochemical techniques and yeast genetics to explore the timing and regulation of this process. By understanding these mechanisms, the research hopes to shed light on issues like aneuploidy, which can lead to various diseases.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for conditions related to DNA replication errors, such as cancer.
How similar studies have gone: While the specific focus on mitotic DNA replication is less explored, similar biochemical approaches in yeast have previously yielded significant insights into cell cycle mechanisms.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Mcclure, Allison — University of Colorado Denver
- Study coordinator: Mcclure, Allison
Related research
Other NIH-funded projects on the same topics.
-
Understanding how alcohol and how couples talk about consent affect intimate partner sexual violence
This project studies how alcohol use and how partners communicate about consent influence intimate partner sexual violence among sexual minority and heterosexual couples.
-
How proteins change and move as heart cells develop
This grant aims to map how protein turnover changes as human iPSCs turn into cardiomyocytes and other cell types, using new labeling and mass-spectrometry methods.
-
Center for Health, Work and Environment
A national center dedicated to improving health in people who work, by studying how jobs affect well-being and safety.
-
Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Expanded antibody-based clues to TB risk in people with HIV
A clinician-scientist seeks to understand how antibodies in people with HIV may drive the progression from latent TB to active TB, with the goal of identifying clues that could guide future care.
-
Human Trisome Project in Latin America Network
A large, multi-site study of people with Down syndrome across Latin America to better understand health and aging in DS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.