Understanding how DNA is replicated during cell division
Molecular mechanisms of DNA replication in mitosis
This study is looking at how cells copy their DNA during cell division, especially when some DNA is left over from earlier, and it's for anyone interested in understanding how mistakes in this process can lead to health problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11018441 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind DNA replication that occurs during mitosis, the phase of the cell cycle when chromosomes are separated into two new cells. It aims to uncover how cells manage to replicate any remaining DNA that wasn't completed during the earlier S phase of the cell cycle. Using purified proteins from budding yeast, the study will employ biochemical techniques and yeast genetics to explore the timing and regulation of this process. By understanding these mechanisms, the research hopes to shed light on issues like aneuploidy, which can lead to various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to DNA replication errors or aneuploidy.
Not a fit: Patients with stable genetic conditions unrelated to DNA replication or aneuploidy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for conditions related to DNA replication errors, such as cancer.
How similar studies have performed: While the specific focus on mitotic DNA replication is less explored, similar biochemical approaches in yeast have previously yielded significant insights into cell cycle mechanisms.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Mcclure, Allison — University of Colorado Denver
- Study coordinator: Mcclure, Allison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.