Understanding how changes in the right ventricle affect heart function in pulmonary hypertension
Official title: Role of right ventricular passive remodeling in ventricular-arterial uncoupling in pulmonary hypertension
Funded at Texas Engineering Experiment Station · NIH-11175771 · Data updated 2026-11-12
This study is looking at how the right side of the heart works in people with pulmonary hypertension, trying to understand how it changes when under pressure and what that means for heart health, with the goal of finding better treatments for those who might face serious issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Engineering Experiment Station NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $642,045 |
| NIH project number | 1R56HL172052-01 |
| Project ID | NIH-11175771 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary hypertension, particularly those experiencing symptoms related to right ventricular dysfunction.
✕Less likely to help
Patients without pulmonary hypertension or those with other unrelated cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates the mechanics of the right ventricle (RV) in patients with pulmonary hypertension (PH), focusing on how the RV adapts to increased pressure and the consequences of this adaptation. The study aims to explore the relationship between RV stiffness, contractility, and the structural changes that occur in the heart muscle. By using advanced imaging techniques and biomechanical analyses, the researchers hope to identify the factors that lead to worsening heart function in PH patients. This understanding could help in developing targeted therapies for those at risk of severe complications.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with pulmonary hypertension, potentially enhancing their heart function and overall health.
How similar studies have gone: Previous studies have shown promising results in understanding RV mechanics in pulmonary hypertension, indicating that this research builds on established findings rather than exploring entirely untested territory.
Where this research is happening
-
Texas Engineering Experiment Station
College Station, United States Active
Researchers
- Principal investigator: Avazmohammadi, Reza — Texas Engineering Experiment Station
- Study coordinator: Avazmohammadi, Reza
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.