Understanding how changes in DNA structure affect blood cancer development
The role of the cohesin complex in hematopoietic transformation and leukemia maintenance
This study is looking at how a protein called cohesin affects the way blood cells develop and how changes in DNA can lead to leukemia, with the hope that understanding these processes will help find new treatments for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11058735 on NIH RePORTER |
What this research studies
This research investigates the role of a protein complex called cohesin in the development and maintenance of leukemia. By examining how the loss of a specific gene affects the three-dimensional structure of DNA and gene expression in blood cells, researchers aim to identify critical changes that lead to cancer. The study uses advanced techniques to analyze chromatin features and gene activity in both mouse and human blood stem cells. Patients may benefit from insights gained about leukemia mechanisms, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS).
Not a fit: Patients with solid tumors or those not diagnosed with blood cancers may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating leukemia by targeting the underlying genetic and epigenetic changes.
How similar studies have performed: Previous research has shown promising results in understanding the role of chromatin structure in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Viny, Aaron D — Columbia University Health Sciences
- Study coordinator: Viny, Aaron D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.