Understanding how changes in chromosome 3 affect squamous cell carcinoma
Elucidating the Consequences of Chromosome 3 Arm Aneuploidies in Squamous Cell Carcinoma
This study is looking at how changes in chromosome 3 might affect the growth and spread of squamous cell carcinoma, a type of cancer that can occur in the lungs, esophagus, and head and neck, to help find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10911320 on NIH RePORTER |
What this research studies
This research investigates the role of chromosome 3 aneuploidies in squamous cell carcinoma (SCC), a common type of cancer affecting the lung, esophagus, and head and neck. The study aims to explore how specific gains and losses of chromosome arms influence cancer development and progression. By using advanced genome engineering techniques, researchers will analyze the effects of these chromosomal changes on various cellular pathways, including lipid signaling and tumorigenesis. This work could lead to new insights into SCC and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with squamous cell carcinoma, particularly those with lung, esophageal, or head and neck cancers.
Not a fit: Patients with other types of cancer or those without chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with squamous cell carcinoma.
How similar studies have performed: While the role of aneuploidy in cancer is a well-studied area, this specific focus on chromosome 3 in SCC is relatively novel and has not been extensively tested.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Taylor, Alison M. — Columbia University Health Sciences
- Study coordinator: Taylor, Alison M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.