Understanding how changes in chromosome 3 affect squamous cell carcinoma
Official title: Elucidating the Consequences of Chromosome 3 Arm Aneuploidies in Squamous Cell Carcinoma
Funded at Columbia University Health Sciences · NIH-10911320 · Data updated 2026-11-12
This study is looking at how changes in chromosome 3 might affect the growth and spread of squamous cell carcinoma, a type of cancer that can occur in the lungs, esophagus, and head and neck, to help find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 21, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $379,293 |
| NIH project number | 5R01CA273723-02 |
| Project ID | NIH-10911320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with squamous cell carcinoma, particularly those with lung, esophageal, or head and neck cancers.
✕Less likely to help
Patients with other types of cancer or those without chromosomal abnormalities may not benefit from this research.
What this research studies
This research investigates the role of chromosome 3 aneuploidies in squamous cell carcinoma (SCC), a common type of cancer affecting the lung, esophagus, and head and neck. The study aims to explore how specific gains and losses of chromosome arms influence cancer development and progression. By using advanced genome engineering techniques, researchers will analyze the effects of these chromosomal changes on various cellular pathways, including lipid signaling and tumorigenesis. This work could lead to new insights into SCC and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with squamous cell carcinoma.
How similar studies have gone: While the role of aneuploidy in cancer is a well-studied area, this specific focus on chromosome 3 in SCC is relatively novel and has not been extensively tested.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Taylor, Alison M. — Columbia University Health Sciences
- Study coordinator: Taylor, Alison M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.