Understanding how certain proteins regulate chromosome separation during the formation of eggs and sperm
Official title: Positive and negative regulation of REC-8 cohesin during meiosis
Funded at Cleveland State University · NIH-10292017 · Data updated 2026-11-12
This study is looking at how a special protein called REC-8 helps make sure chromosomes separate correctly during the formation of sperm and eggs, which is important for healthy reproduction, and it aims to find out more about the genes that influence this process to better understand issues like birth defects and miscarriages.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2021 |
| Award (this year) | $445,500 |
| NIH project number | 1R15GM143731-01 |
| Project ID | NIH-10292017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals or families with a history of congenital abnormalities or recurrent miscarriages.
✕Less likely to help
Patients with no history of genetic issues or those not affected by congenital abnormalities may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the separation of chromosomes during meiosis, which is crucial for producing healthy sperm and eggs. It focuses on the role of a specific protein, REC-8, and how it ensures proper chromosome segregation. By using genetic screening in the model organism C. elegans, the researchers aim to identify genes that affect REC-8 function and understand how these genes contribute to the meiotic process. This work could provide insights into the causes of congenital abnormalities and miscarriages related to chromosome segregation errors.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for conditions related to congenital abnormalities and miscarriages.
How similar studies have gone: Other research has shown success in understanding meiotic processes and their implications for fertility, making this approach promising.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Severson, Aaron F — Cleveland State University
- Study coordinator: Severson, Aaron F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.