Circadian Clock and Diet: How calories and timing affect aging
Official title: Circadian Clock and Dietary Restriction
Funded at Cleveland State University · NIH-11372830 · Data updated 2026-11-12
A study exploring how calorie restriction and daily rhythms interact to influence aging-related metabolism and signaling in mice, with potential relevance to human aging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 15, 2011 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $483,243 |
| NIH project number | 5R01AG039547-15 |
| Project ID | NIH-11372830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals interested in or affected by aging, metabolic health, or chrononutrition research, including those pursuing dietary interventions.
✕Less likely to help
Individuals without interest in dietary timing or aging research are unlikely to benefit.
What this research studies
This project looks at how eating less and changing meal timing shape the body’s aging processes by studying a key metabolic pathway called mTOR. Using normal and clock-gene mutant mice, researchers will compare how calorie restriction, fasting, and ad libitum feeding alter circadian rhythms and mTOR signaling in living organisms and in tissue samples. The goal is to understand how circadian timing contributes to metabolic changes during calorie restriction and whether these changes promote longevity. Findings could reveal targets to support healthy aging in people who pursue calorie restriction or time-restricted eating.
Why it matters
Potential benefit: If successful, this work could identify circadian-based strategies to optimize calorie restriction for healthier aging in humans.
How similar studies have gone: Previous research shows that circadian rhythms influence metabolism and aging, with calorie restriction having beneficial metabolic effects in animal models; this study extends those insights.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Kondratov, Roman V — Cleveland State University
- Study coordinator: Kondratov, Roman V
Related research
Other NIH-funded projects on the same topics.
-
How ATP8B1 and ABCA1 affect cholesterol and inflammation in heart disease
A research project is exploring how specific cholesterol-related proteins influence inflammation and heart disease to uncover new ways to prevent or treat atherosclerosis.
-
Wireless pudendal nerve stimulation to reduce urine leakage after childbirth
A tiny wireless device that uses mechanical motion to make gentle electrical pulses to the nerve that controls the urethral muscle, aimed at helping women with stress urinary incontinence after vaginal delivery.
-
New LC-MS/MS instrument to boost research and education at CSU
CSU is requesting a high-end LC-MS/MS instrument to upgrade its research labs and provide hands-on training for students and faculty.
-
Multi-functional 3D-Printed Dental Implants to Prevent Peri-Implant Infections
A patient-friendly implant made with a special 3D-printed material that fights infection and helps bone integrate with the implant.
-
Lowering PUM1 to raise fetal hemoglobin in adults
Seeing if reducing a protein called PUM1 can raise protective fetal hemoglobin in adults with sickle cell disease or beta‑thalassemia.
-
A smart implant to help rebuild large muscle losses after injury
This project aims to use a self-powered implant that delivers muscle cells and gentle electrical pulses from everyday limb movement to help people with large traumatic muscle loss rebuild working muscle.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.