How ATP8B1 and ABCA1 affect cholesterol and inflammation in heart disease
Official title: Phosphatidylinositol Metabolism and Trafficking in Atherosclerosis and Inflammation
Funded at Cleveland State University · NIH-11377378 · Data updated 2026-11-12
A research project is exploring how specific cholesterol-related proteins influence inflammation and heart disease to uncover new ways to prevent or treat atherosclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | April 1, 2020 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $487,457 |
| NIH project number | 5R01HL148158-08 |
| Project ID | NIH-11377378 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with or at risk for atherosclerotic cardiovascular disease or related liver/cholesterol disorders may benefit from advances arising from this research.
✕Less likely to help
If a patient does not have cholesterol-related disease or ASCVD risk, direct benefits may be limited, though broader scientific insights could still emerge.
What this research studies
This grant studies how dysfunctional responses to cholesterol and bacterial components contribute to chronic inflammation and cardiovascular disease. Researchers will examine the roles of ATP8B1 and ABCA1 in lipid metabolism and membrane remodeling, using advanced lab techniques to understand how these proteins affect inflammation in macrophages and liver cells. The goal is to identify mechanisms that drive atherosclerosis and related liver disease, with the potential to guide new therapies. By translating molecular findings to human health, this work could inform future interventions for patients at risk of ASCVD.
Why it matters
Potential benefit: Understanding these mechanisms could lead to new targets for preventing or treating atherosclerosis and related inflammatory conditions.
How similar studies have gone: Other studies linking lipid transport proteins to inflammation have yielded actionable insights, suggesting this approach could yield meaningful progress.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Gulshan, Kailash — Cleveland State University
- Study coordinator: Gulshan, Kailash
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.