Understanding how certain proteins communicate within cells
Official title: Decoding mitogen-activated protein kinase signaling networks
Funded at Yale University · NIH-11079443 · Data updated 2026-11-12
This study is looking at how cells communicate and respond to different signals, using yeast to find new proteins that work with important signaling molecules, which could help us discover new treatments for diseases caused by problems in cell signaling.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $326,625 |
| NIH project number | 5R35GM153265-02 |
| Project ID | NIH-11079443 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to cellular signaling abnormalities.
✕Less likely to help
Patients with conditions unrelated to cellular signaling pathways may not receive any benefit from this research.
What this research studies
This research investigates the signaling pathways that help cells respond to various internal and external signals. By using innovative yeast-based screening methods, the team aims to identify new proteins that interact with key signaling molecules known as MAPKs. The study will also explore how these interactions influence cellular functions and the specificity of signaling outputs. Patients may benefit from insights gained about these pathways, which could lead to new therapeutic targets for diseases related to cell signaling dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by faulty cell signaling.
How similar studies have gone: Previous research has shown success in understanding MAPK pathways, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Turk, Benjamin E — Yale University
- Study coordinator: Turk, Benjamin E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.