Understanding how certain immune cells develop and function in the intestines
Official title: Mechanisms Controlling the Development and Function of Intestinal Effector Treg cells
Funded at University of Alabama at Birmingham · NIH-11015028 · Data updated 2026-11-12
This study is looking at how certain immune cells in the gut work and how they can be controlled, which could help people with inflammatory bowel disease (IBD) understand their condition better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 21, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $707,788 |
| NIH project number | 5R01AI164717-03 |
| Project ID | NIH-11015028 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease or related gastrointestinal disorders.
✕Less likely to help
Patients with non-inflammatory bowel conditions or those without immune dysregulation may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the development and function of intestinal effector Treg cells, which play a crucial role in maintaining immune balance in the gut. By studying the interplay between specific signaling pathways, the researchers aim to uncover how these immune cells can be regulated, particularly in the context of inflammatory bowel disease (IBD). The approach involves both mouse models and human samples to gain insights into the immune responses in the intestines. Patients may benefit from a better understanding of their condition and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from inflammatory bowel disease.
How similar studies have gone: Other research has shown promising results in understanding immune regulation in the gut, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Weaver, Casey T — University of Alabama at Birmingham
- Study coordinator: Weaver, Casey T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.