Understanding how cellular processes can rejuvenate the nuclear envelope
Official title: The mechanism of nucleophagy in rejuvenating the nuclear envelope
Funded at Yale University · NIH-11021997 · Data updated 2026-11-12
This study is looking at how cells clean up and refresh their nucleus, which is like the control center of the cell, using yeast to learn more about this process and how it might help us stay healthy as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $656,709 |
| NIH project number | 1R01AG090465-01 |
| Project ID | NIH-11021997 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related disorders or conditions linked to nuclear dysfunction.
✕Less likely to help
Patients with acute, non-age-related conditions or those not experiencing any age-related impairments may not benefit from this research.
What this research studies
This research investigates the process of nucleophagy, which is the cellular mechanism responsible for the turnover of components within the nucleus. By studying the yeast model, the researchers aim to uncover the molecular steps involved in this process and how it relates to aging and age-related disorders. The focus is on understanding how the nuclear envelope, which protects the nucleus, can be rejuvenated through the removal of toxic substances and dysfunctional components. This could lead to insights into how to maintain cellular health as we age.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases by improving nuclear function.
How similar studies have gone: While the specific approach of nucleophagy is relatively novel, previous studies on macroautophagy have shown promising results in extending lifespan and improving cellular health.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Lusk, Charles Patrick — Yale University
- Study coordinator: Lusk, Charles Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.