Understanding how cells maintain their identity during division
Official title: Maintenance of cellular memory during replication
Funded at University of Colorado Denver · NIH-11011127 · Data updated 2026-11-12
This study is looking at how cells keep their unique roles and abilities when they divide, focusing on the DNA packaging and how it changes during this process, which could help us understand more about growth and diseases related to cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | January 15, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $427,571 |
| NIH project number | 1R35GM156411-01 |
| Project ID | NIH-11011127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal cell growth, such as cancer or developmental disorders.
✕Less likely to help
Patients with stable, non-proliferative conditions or those not affected by cellular growth issues may not benefit from this research.
What this research studies
This research investigates how cells preserve their identity and function during the process of division. By examining the chromatin landscape, which is the structure that packages DNA, the study aims to uncover the dynamic changes that occur as cells replicate. Using innovative techniques in structural epigenomics, researchers will track how specific proteins are recruited to DNA after replication, and how these processes influence gene expression throughout the cell cycle. This work could provide insights into developmental biology and diseases related to cell growth and differentiation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases that involve abnormal cell growth and differentiation.
How similar studies have gone: Previous research in epigenetics has shown promising results in understanding cellular mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Ramachandran, Srinivas — University of Colorado Denver
- Study coordinator: Ramachandran, Srinivas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.