Understanding how cells maintain their identity during division
Maintenance of cellular memory during replication
This study is looking at how cells keep their unique roles and abilities when they divide, focusing on the DNA packaging and how it changes during this process, which could help us understand more about growth and diseases related to cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11011127 on NIH RePORTER |
What this research studies
This research investigates how cells preserve their identity and function during the process of division. By examining the chromatin landscape, which is the structure that packages DNA, the study aims to uncover the dynamic changes that occur as cells replicate. Using innovative techniques in structural epigenomics, researchers will track how specific proteins are recruited to DNA after replication, and how these processes influence gene expression throughout the cell cycle. This work could provide insights into developmental biology and diseases related to cell growth and differentiation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal cell growth, such as cancer or developmental disorders.
Not a fit: Patients with stable, non-proliferative conditions or those not affected by cellular growth issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases that involve abnormal cell growth and differentiation.
How similar studies have performed: Previous research in epigenetics has shown promising results in understanding cellular mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Ramachandran, Srinivas — University of Colorado Denver
- Study coordinator: Ramachandran, Srinivas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.