Understanding how cell states change over time with single-cell multiomics
Official title: Studying the Regulatory Dynamics with Single-cell Multiomics
Funded at New York Genome Center · NIH-11014674 · Data updated 2026-11-12
Researchers will study how individual cells change their gene regulation over time, using advanced single-cell multiomics, to learn more about aging and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,004,955 |
| NIH project number | 4DP2GM154011-02 |
| Project ID | NIH-11014674 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults affected by aging-related conditions or cancers where brain cell regulation is a factor.
✕Less likely to help
Early-stage research may not yet translate into direct benefits for patients in the near term.
What this research studies
This project will map how epigenetic marks and gene activity evolve in single cells as they transition between states in aging brains and cancer-related contexts. Using cutting-edge single-cell multiomics, the team aims to track writing and erasing of epigenomic signals to understand regulatory dynamics. The findings could reveal why certain cell types worsen with age and contribute to cancer biology, potentially guiding new approaches to treatment or prevention.
Why it matters
Potential benefit: If successful, the work could lead to better understanding of aging-related changes in cells that influence cancer and neurodegeneration, informing future therapies.
How similar studies have gone: Previous single-cell studies have shown that regulatory dynamics can impact disease progression, but this project advances the temporal aspect using multiomics.
Where this research is happening
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New York Genome Center
New York, United States Active
Researchers
- Principal investigator: Zhu, Chenxu — New York Genome Center
- Study coordinator: Zhu, Chenxu
Related research
Other NIH-funded projects on the same topics.
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New York Genome Center’s project on somatic mosaicism across human tissues
A nationwide effort to build a high-quality catalog of somatic genetic changes found in healthy tissues from people of diverse backgrounds, with the goal of better understanding aging and disease.
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Understanding genetic networks in autism and bipolar disorders to improve biology and treatment
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.