Understanding how brain stimulation affects gene activity in humans
Deciphering the genomic mechanisms underlying the physiology of human brain stimulation
This study is looking at how brain stimulation affects the way certain genes work in people who have had brain surgery, and it aims to help us understand how these therapies might improve memory and brain function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10834634 on NIH RePORTER |
What this research studies
This research investigates the effects of brain stimulation on gene expression by analyzing high-quality neural tissue obtained from neurosurgical patients. The team will conduct a series of experiments comparing brain tissue from patients who have undergone neurostimulation with that from control subjects who have not. Using advanced techniques like single nuclei RNA-sequencing and ATAC-sequencing, the study aims to uncover how stimulation influences brain circuits and memory-related gene activity. The findings could provide insights into the biological mechanisms behind brain stimulation therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are neurosurgical patients undergoing procedures that involve brain stimulation.
Not a fit: Patients with brain disorders who are not candidates for neurosurgery or brain stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved brain stimulation therapies that enhance memory and cognitive function in patients with brain disorders.
How similar studies have performed: Previous research has shown promising results in understanding gene expression changes related to brain stimulation, indicating that this approach has potential for significant findings.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Lega, Bradley C — Ut Southwestern Medical Center
- Study coordinator: Lega, Bradley C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.