Understanding how brain signals control inhibitory synapses
Official title: Mechanisms of transcriptional regulation to control inhibitory synaptic plasticity
Funded at University of Colorado Denver · NIH-10900343 · Data updated 2026-11-12
This study is looking at how certain proteins and tiny molecules in the brain help control the connections between nerve cells, which could lead to better treatments for brain disorders that affect communication and behavior.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $36,591 |
| NIH project number | 1F31NS137619-01 |
| Project ID | NIH-10900343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with brain disorders characterized by synaptic dysfunction, such as epilepsy or anxiety disorders.
✕Less likely to help
Patients with non-neurological conditions or those not affected by synaptic plasticity issues may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms behind inhibitory synaptic plasticity in the brain, focusing on how certain proteins and microRNAs regulate the strength and clustering of inhibitory synapses. By examining the role of transcription factors and signaling pathways, the study aims to uncover how these processes affect neuronal communication and behavior. Patients may benefit from insights gained into brain disorders linked to synaptic dysfunction, as the findings could lead to new therapeutic strategies. The research employs advanced techniques such as electrophysiology and confocal microscopy to analyze these complex interactions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for brain disorders by enhancing our understanding of synaptic regulation.
How similar studies have gone: Previous research has shown promising results in understanding synaptic plasticity, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Wolfe, Sarah E — University of Colorado Denver
- Study coordinator: Wolfe, Sarah E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.