Understanding how brain cells develop and differentiate in organoids
Official title: Uncovering the dynamics and regulatory logic of cell fate specification in cerebral organoid data
Funded at Yale University · NIH-11167287 · Data updated 2026-11-12
This study is looking at how certain genes help brain cells grow and develop, especially the stem cells that are important for brain health, to learn more about conditions like autism and find better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 9, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $635,408 |
| NIH project number | 2R01NS139561-06A1 |
| Project ID | NIH-11167287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those on the autism spectrum.
✕Less likely to help
Patients with neurodevelopmental disorders unrelated to the mechanisms being studied may not receive direct benefits from this research.
What this research studies
This research investigates the gene regulatory networks that control the development of brain cells, specifically focusing on radial glia, which are the stem cells of the human brain. By using advanced techniques such as cortical organoids, single-cell CRISPR screens, and spatial transcriptomics, the study aims to uncover the mechanisms behind neurodevelopmental disorders like autism. Patients may benefit from insights gained about how brain cells differentiate and function, potentially leading to new treatment protocols. The research will analyze brain cell behavior at various developmental stages to better understand the processes involved in brain formation.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for neurodevelopmental disorders, including autism.
How similar studies have gone: Previous research has shown promise in understanding brain development through similar methodologies, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Krishnaswamy, Smita — Yale University
- Study coordinator: Krishnaswamy, Smita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.