Understanding how Alport syndrome affects kidney function
Official title: Elucidating novel mechanisms in the pathogenesis of Alport syndrome
Funded at Ut Southwestern Medical Center · NIH-11028068 · Data updated 2026-11-12
This study is looking into how certain proteins in kidney cells are linked to Alport syndrome, which causes kidney problems, to help find new ways to treat the condition and improve care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $424,278 |
| NIH project number | 1R01DK141873-01 |
| Project ID | NIH-11028068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alport syndrome, particularly those with X-linked Alport syndrome.
✕Less likely to help
Patients with other forms of kidney disease unrelated to Alport syndrome may not benefit from this research.
What this research studies
This research investigates the mechanisms behind Alport syndrome, a genetic condition that leads to chronic kidney disease. It focuses on the role of specific collagen proteins in kidney cells and how their dysfunction contributes to the disease. By studying both glomerular and non-glomerular cells, the research aims to uncover new insights into the disease's progression and identify potential therapeutic targets. Patients may benefit from a better understanding of their condition and the development of new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with Alport syndrome, potentially slowing disease progression and enhancing kidney function.
How similar studies have gone: Previous research has shown promise in understanding the genetic and cellular mechanisms of kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Marciano, Denise K — Ut Southwestern Medical Center
- Study coordinator: Marciano, Denise K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.