Understanding how alcohol affects liver function and circadian rhythms
Circadian and mitochondrial dysfunction in alcohol-related liver disease
This study looks at how drinking alcohol over a long time affects liver health, especially how it messes with the liver's energy production and daily rhythms, to help find new ways to protect and improve liver function for people dealing with alcohol-related liver issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11061407 on NIH RePORTER |
What this research studies
This research investigates the impact of chronic alcohol consumption on liver health, specifically focusing on how it disrupts mitochondrial function and circadian rhythms. By studying the molecular mechanisms behind alcohol-related liver disease, the research aims to uncover how these disruptions contribute to liver damage. The approach includes using animal models to observe changes in liver function and metabolism in response to alcohol intake, providing insights into potential therapeutic targets for improving liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of chronic alcohol consumption who may be experiencing liver-related health issues.
Not a fit: Patients who do not consume alcohol or have liver disease from non-alcoholic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating alcohol-related liver disease.
How similar studies have performed: Other research has shown promising results in understanding the relationship between circadian rhythms and liver function, suggesting that this approach could yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Bailey, Shannon Marie — University of Alabama at Birmingham
- Study coordinator: Bailey, Shannon Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.