Understanding how alcohol affects liver function and circadian rhythms
Official title: Circadian and mitochondrial dysfunction in alcohol-related liver disease
Funded at University of Alabama at Birmingham · NIH-11061407 · Data updated 2026-11-12
This study looks at how drinking alcohol over a long time affects liver health, especially how it messes with the liver's energy production and daily rhythms, to help find new ways to protect and improve liver function for people dealing with alcohol-related liver issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | May 10, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $457,851 |
| NIH project number | 5R01AA029072-03 |
| Project ID | NIH-11061407 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of chronic alcohol consumption who may be experiencing liver-related health issues.
✕Less likely to help
Patients who do not consume alcohol or have liver disease from non-alcoholic causes may not benefit from this research.
What this research studies
This research investigates the impact of chronic alcohol consumption on liver health, specifically focusing on how it disrupts mitochondrial function and circadian rhythms. By studying the molecular mechanisms behind alcohol-related liver disease, the research aims to uncover how these disruptions contribute to liver damage. The approach includes using animal models to observe changes in liver function and metabolism in response to alcohol intake, providing insights into potential therapeutic targets for improving liver health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating alcohol-related liver disease.
How similar studies have gone: Other research has shown promising results in understanding the relationship between circadian rhythms and liver function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Bailey, Shannon Marie — University of Alabama at Birmingham
- Study coordinator: Bailey, Shannon Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.