Understanding how a specific mutation affects RNA processing in blood disorders
Official title: Altered RNA fates due to an MDS driver mutation in SF3B1
Funded at Yale University · NIH-11003760 · Data updated 2026-11-12
This study is looking at how a specific mutation in the SF3B1 gene affects the way your body processes RNA in people with myelodysplastic syndromes (MDS), which is a blood disorder, to help find new treatment options that could improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $550,157 |
| NIH project number | 5R01HL167071-02 |
| Project ID | NIH-11003760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with myelodysplastic syndromes, particularly those with the SF3B1 mutation.
✕Less likely to help
Patients without myelodysplastic syndromes or those not carrying the SF3B1 mutation may not benefit from this research.
What this research studies
This research investigates the impact of the SF3B1 mutation on RNA processing in patients with myelodysplastic syndromes (MDS), a blood disorder often associated with aging. The study focuses on how this mutation alters transcription and splicing mechanisms, which are crucial for proper gene expression. By examining the changes in RNA dynamics and chromatin organization, the research aims to uncover the underlying mechanisms that contribute to the disease phenotype. Patients may benefit from insights that could lead to new therapeutic strategies targeting these molecular changes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with myelodysplastic syndromes.
How similar studies have gone: Previous research has shown that targeting splicing factors can lead to significant advancements in understanding blood disorders, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Pillai, Manoj M. — Yale University
- Study coordinator: Pillai, Manoj M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.