Understanding genetic risks for blood cancers
Official title: Myeloid Malignancy Variant Curation Expert Panel
Funded at Northwestern University at Chicago · NIH-10887719 · Data updated 2026-11-12
This study is looking at specific genetic changes that might make people more likely to develop certain blood cancers, and it aims to help patients and their families understand their risks better and find more personalized ways to manage their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | April 20, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $322,766 |
| NIH project number | 2U24CA258118-05 |
| Project ID | NIH-10887719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of myeloid malignancies or those who have been diagnosed with related blood cancers.
✕Less likely to help
Patients without a genetic predisposition to myeloid malignancies or those with unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on identifying genetic variants that predispose individuals to myeloid malignancies, which are types of blood cancers. The project involves a collaborative effort to curate and classify these genetic variants, particularly those in genes like RUNX1, DDX41, and GATA2. By developing standardized rules for variant curation, the research aims to improve the understanding of how these genetic factors contribute to cancer risk. Patients and families may benefit from this work through better risk assessment and personalized management strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of individuals at risk for myeloid malignancies, enabling earlier detection and tailored treatment options.
How similar studies have gone: Previous research has successfully identified genetic variants associated with blood cancers, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Godley, Lucy Ann — Northwestern University at Chicago
- Study coordinator: Godley, Lucy Ann
Related research
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Myeloid Cancer Gene Variant Curation Expert Panel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.