Understanding brain function in Fragile X Syndrome
Official title: Translational medicine and mechanistic studies of brain neurophysiology in Fragile X Syndrome
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11179534 · Data updated 2026-11-12
This study is looking at how Fragile X Syndrome affects the brain in both mice and people to find out what causes the challenges faced by those with the condition, with the goal of creating better treatments and understanding for everyone affected by FXS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 25, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $84,059 |
| NIH project number | 3U54HD104461-05S1 |
| Project ID | NIH-11179534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome, including those with varying degrees of severity.
✕Less likely to help
Patients without a diagnosis of Fragile X Syndrome or those with unrelated neurodevelopmental disorders may not benefit from this research.
What this research studies
This research investigates the neurophysiological abnormalities associated with Fragile X Syndrome (FXS) by comparing findings in both mice and humans. The team employs a mechanistic approach to identify the underlying causes of brain dysfunction, utilizing advanced techniques such as whole brain network modeling and molecular analysis. By bridging the gap between preclinical and clinical studies, the research aims to develop biomarkers and improve treatment discovery for individuals with FXS. The focus is on recognizing the diversity within FXS to tailor approaches for better understanding and treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with Fragile X Syndrome.
How similar studies have gone: Previous research has shown promising results in understanding neurophysiological mechanisms in related conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Erickson, Craig — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Erickson, Craig
Related research
Other NIH-funded projects on the same topics.
-
Understanding Fragile X Syndrome: How it progresses and affects daily life
A long-term study using existing Fragile X data to map how the condition changes over time in children and young adults, including how autism, race, and location influence outcomes.
-
Sleep and mood links in Fragile X Syndrome
A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.
-
Connecting 3D genome misfolding to gene silencing in Fragile X syndrome
A study in people with Fragile X syndrome focuses on how 3D genome folding errors may turn off important genes, contributing to the condition’s features.
-
Cortical circuit problems in Fragile X mice and people
Researchers are studying how brain circuits go awry in Fragile X syndrome by comparing mice and people to understand why certain brain rhythms and responses are altered.
-
Brain biology in fragile X syndrome: how brain signals unfold and vary in patients
This grant supports research to understand brain signals and why symptoms vary in people with fragile X syndrome, aiming to translate findings into better care.
-
Brain research on Fragile X Syndrome to improve therapies
A multi-year program studies brain function and differences in Fragile X Syndrome to help develop better treatments for people with FXS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.