Understanding brain function in Fragile X Syndrome
Translational medicine and mechanistic studies of brain neurophysiology in Fragile X Syndrome
This study is looking at how Fragile X Syndrome affects the brain in both mice and people to find out what causes the challenges faced by those with the condition, with the goal of creating better treatments and understanding for everyone affected by FXS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11179534 on NIH RePORTER |
What this research studies
This research investigates the neurophysiological abnormalities associated with Fragile X Syndrome (FXS) by comparing findings in both mice and humans. The team employs a mechanistic approach to identify the underlying causes of brain dysfunction, utilizing advanced techniques such as whole brain network modeling and molecular analysis. By bridging the gap between preclinical and clinical studies, the research aims to develop biomarkers and improve treatment discovery for individuals with FXS. The focus is on recognizing the diversity within FXS to tailor approaches for better understanding and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome, including those with varying degrees of severity.
Not a fit: Patients without a diagnosis of Fragile X Syndrome or those with unrelated neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with Fragile X Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding neurophysiological mechanisms in related conditions, suggesting potential for success in this novel approach.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Erickson, Craig — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Erickson, Craig
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.