Brain biology in fragile X syndrome: how brain signals unfold and vary in patients
Official title: Mechanistic and translational medicine studies of brain neurophysiology and phenotypic heterogeneity in fragile X syndrome
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11419206 · Data updated 2026-11-12
This grant supports research to understand brain signals and why symptoms vary in people with fragile X syndrome, aiming to translate findings into better care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 18, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $321,043 |
| NIH project number | 5P50HD118717-02 |
| Project ID | NIH-11419206 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with fragile X syndrome and their families who participate in research advisory activities or future studies related to brain function and clinical care.
✕Less likely to help
People without fragile X syndrome or those not involved in advisory or translational activities may not directly benefit.
What this research studies
This center brings together multiple projects to study brain activity and how it relates to the range of symptoms seen in fragile X syndrome. A centralized administrative core coordinates research activities, governance, stakeholder engagement, and dissemination of results across sites. The work seeks to connect basic brain biology with clinical features to inform future therapies and care strategies for individuals with fragile X. Families and patient perspectives will be incorporated through advisory councils to guide research priorities and communication.
Why it matters
Potential benefit: If successful, the research could lead to clearer understanding of fragile X brain biology and pave the way for targeted treatments and improved patient care.
How similar studies have gone: Prior work in fragile X has shown links between brain signaling and behavior, but this center aims for deeper mechanistic and translational connections across sites.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Erickson, Craig — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Erickson, Craig
Related research
Other NIH-funded projects on the same topics.
-
Understanding Fragile X Syndrome: How it progresses and affects daily life
A long-term study using existing Fragile X data to map how the condition changes over time in children and young adults, including how autism, race, and location influence outcomes.
-
Sleep and mood links in Fragile X Syndrome
A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.
-
Connecting 3D genome misfolding to gene silencing in Fragile X syndrome
A study in people with Fragile X syndrome focuses on how 3D genome folding errors may turn off important genes, contributing to the condition’s features.
-
Cortical circuit problems in Fragile X mice and people
Researchers are studying how brain circuits go awry in Fragile X syndrome by comparing mice and people to understand why certain brain rhythms and responses are altered.
-
Brain research on Fragile X Syndrome to improve therapies
A multi-year program studies brain function and differences in Fragile X Syndrome to help develop better treatments for people with FXS.
-
Understanding anxiety in Fragile X syndrome across childhood
A study follows children and young people with Fragile X syndrome to understand how anxiety starts, stays, and what predicts it over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.