Brain research on Fragile X Syndrome to improve therapies
Official title: Mechanistic and translational medicine studies of brain neurophysiology and phenotypic heterogeneity in fragile X syndrome
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11419164 · Data updated 2026-11-12
A multi-year program studies brain function and differences in Fragile X Syndrome to help develop better treatments for people with FXS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 18, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,881,985 |
| NIH project number | 5P50HD118717-02 |
| Project ID | NIH-11419164 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with Fragile X Syndrome and adults with Fragile X-related phenotypes who participate in brain-function studies or biomarker assessments.
✕Less likely to help
Individuals not affected by Fragile X Syndrome or those not contributing to biomarker or translational studies may not directly benefit.
What this research studies
This grant supports a translational research effort that links studies in children and mouse models to understand how Fragile X affects brain activity and behavior. Researchers will look for biomarkers and patterns of brain function across development, using both human data and animal studies. The goal is to translate findings into more precise, effective therapies for people with Fragile X across ages.
Why it matters
Potential benefit: If successful, the work could lead to targeted treatments and better biomarkers to track progress in people with Fragile X.
How similar studies have gone: Previous work established biomarkers in adults with Fragile X and in mouse models, providing a foundation for translational approaches.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Erickson, Craig — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Erickson, Craig
Related research
Other NIH-funded projects on the same topics.
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Understanding Fragile X Syndrome: How it progresses and affects daily life
A long-term study using existing Fragile X data to map how the condition changes over time in children and young adults, including how autism, race, and location influence outcomes.
-
Sleep and mood links in Fragile X Syndrome
A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.
-
Connecting 3D genome misfolding to gene silencing in Fragile X syndrome
A study in people with Fragile X syndrome focuses on how 3D genome folding errors may turn off important genes, contributing to the condition’s features.
-
Cortical circuit problems in Fragile X mice and people
Researchers are studying how brain circuits go awry in Fragile X syndrome by comparing mice and people to understand why certain brain rhythms and responses are altered.
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Brain biology in fragile X syndrome: how brain signals unfold and vary in patients
This grant supports research to understand brain signals and why symptoms vary in people with fragile X syndrome, aiming to translate findings into better care.
-
Understanding anxiety in Fragile X syndrome across childhood
A study follows children and young people with Fragile X syndrome to understand how anxiety starts, stays, and what predicts it over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.