Understanding and Treating High-Grade Uterine Cancer by Studying PP2A
Official title: Interrogating PP2A to understand and treat high-grade endometrial carcinoma
Funded at University of Michigan at Ann Arbor · NIH-11268799 · Data updated 2026-11-12
A patient-focused look at how researchers are using mouse models with PP2A changes to learn why high-grade uterine cancers grow and how to stop them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 2, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $512,292 |
| NIH project number | 1R01CA307725-01 |
| Project ID | NIH-11268799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women with high-grade endometrial carcinoma or those at risk due to specific genetic alterations, or later patients who may benefit from new therapies derived from this research.
✕Less likely to help
Patients whose cancer does not involve the studied genetic pathways or who are not candidates for the resulting therapies may not experience direct benefit.
What this research studies
This project uses engineered mice to model high-grade endometrial carcinomas that often carry TP53 and PPP2R1A mutations. By studying how PP2A components affect tumor development in the uterine lining, scientists aim to pinpoint new targets for therapy. The work is designed to translate findings into preclinical tests for drugs that could benefit women with aggressive uterine cancer. The research team will generate and analyze animals with specific genetic alterations to mirror human disease, and will examine tumor behavior and response to potential treatments. Overall, the goal is to connect molecular drivers to effective treatments for patients with high-risk endometrial cancer.
Why it matters
Potential benefit: If successful, the work could lead to targeted therapies that improve survival for women with aggressive uterine cancer.
How similar studies have gone: Prior studies using similar genetic mouse models have informed understanding of disease drivers and supported development of targeted approaches; this project extends that work to PP2A-related targets.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: O'connor, Caitlin — University of Michigan at Ann Arbor
- Study coordinator: O'connor, Caitlin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.