Ultra-low-temperature NMR-DNP tool for proteins and materials
Official title: Ultra-low-temperature (6 K) static NMR-DNP for metalloproteins, proteins in cells, and materials
Funded at Doty Scientific, INC. · NIH-11251938 · Data updated 2026-11-12
A new ultra-low-temperature NMR technology project aims to boost how clearly we can study Alzheimer’s-related proteins and other biomolecules.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Doty Scientific, INC. NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $946,077 |
| NIH project number | 5R44GM148111-03 |
| Project ID | NIH-11251938 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable in this technical, instrument-focused grant.
✕Less likely to help
Patients may not directly benefit unless the technology translates to therapies.
What this research studies
This project develops a cutting-edge NMR technology that operates at extremely low temperatures to dramatically improve signal strength, enabling detailed studies of metalloproteins, proteins inside cells, and materials. By combining ultra-low-temperature NMR with dynamic nuclear polarization, researchers hope to obtain clearer atomic-scale information about Alzheimer’s-related amyloid fibrils and other biological samples. The work addresses gaps in available, affordable ULT NMR instrumentation and aims to create a more accessible platform for high-resolution structural studies. If successful, the technology could accelerate understanding of disease-related proteins and inform drug development. The project will be conducted at a private company with specialized facilities and focused on methodological advancement rather than a single clinical trial.”,
Why it matters
Potential benefit: Could enable more precise structural insights into Alzheimer’s-related proteins, potentially guiding future therapies.
How similar studies have gone: Previous work has demonstrated atomic-resolution structures of Alzheimer’s amyloid fibrils using ssNMR, but ULT-DNP in non-spinning static samples is still emerging.
Where this research is happening
-
Doty Scientific, INC.
Columbia, United States Active
Researchers
- Principal investigator: Doty, Francis David — Doty Scientific, INC.
- Study coordinator: Doty, Francis David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.