Low-loss Bidirectional THz Couplers to Enable Affordable MAS-DNP-NMR
Funded at Doty Scientific, INC. · NIH-11409429 · Data updated 2026-11-12
Aimed at making a powerful NMR technology more affordable so researchers can study proteins and disease-related structures, including Alzheimer’s-related amyloid fibrils.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Doty Scientific, INC. NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $994,403 |
| NIH project number | 2R44GM156167-02 |
| Project ID | NIH-11409429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient trial; research advances in structural biology that could eventually inform patient therapies.
✕Less likely to help
Direct patient benefit is not guaranteed; this is a technology development grant.
What this research studies
This project develops new THz couplers to dramatically reduce costs and enable broader use of MAS-DNP-NMR in solid-state biomolecular studies. By improving microwave efficiency and reducing equipment size, it could let more labs access high-resolution structural data on disease-associated proteins. The work involves innovative cavity designs and testing on model systems to demonstrate practicality and performance. If successful, researchers could characterize biological structures relevant to Alzheimer’s and other diseases at atomic detail.
Why it matters
Potential benefit: If successful, this could lower barriers to obtaining detailed molecular structures of disease-related proteins, accelerating drug design and understanding of conditions like Alzheimer’s disease.
How similar studies have gone: Previous MAS-DNP approaches exist, but affordable, broadly applicable designs with high efficiency are still needed, making this a promising but developing area.
Where this research is happening
-
Doty Scientific, INC.
Columbia, United States Active
Researchers
- Principal investigator: Doty, Francis David — Doty Scientific, INC.
- Study coordinator: Doty, Francis David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.