Developing new technology to improve NMR imaging for Alzheimer's and cancer research
Low-loss Bi-directional THz Couplers to Enable Affordable MAS-DNP-NMR
This study is working on new technology to make it easier and cheaper to get detailed images of tiny structures in the brain, which could help us better understand and treat diseases like Alzheimer's and cancer.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Doty Scientific, INC. NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11007872 on NIH RePORTER |
What this research studies
This research focuses on creating low-loss bi-directional THz couplers to enhance the affordability and efficiency of dynamic nuclear polarization (DNP) with magic angle spinning (MAS) in solid-state NMR imaging. By improving the technology used in NMR, the research aims to provide clearer atomic-resolution structures of amyloid fibrils associated with Alzheimer's Disease and other conditions. The approach involves developing novel microwave systems that can operate more effectively without the high costs and limitations of current gyrotron technology. This could lead to significant advancements in understanding and treating diseases like Alzheimer's and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by Alzheimer's Disease or cancer who may benefit from improved diagnostic imaging techniques.
Not a fit: Patients with conditions unrelated to Alzheimer's or cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accessible and effective imaging techniques for diagnosing and studying Alzheimer's Disease and cancer.
How similar studies have performed: Other research has shown promise in improving NMR imaging techniques, but this specific approach using low-loss THz couplers is relatively novel.
Where this research is happening
Columbia, United States
- Doty Scientific, INC. — Columbia, United States (Active)
Researchers
- Principal investigator: Doty, Francis David — Doty Scientific, INC.
- Study coordinator: Doty, Francis David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.